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KMID : 0358420090520111164
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 11 p.1164 ~ p.1168
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One case of Lynch type II syndrome
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Kim Kyoung-Jin
Kim Nam-Eui
Lee Yong-Ho
Kim Kyoung-A
Hong Sang-Ki
Baek So-Kyung
Ju Myoung-Jin
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Abstract
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Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc. The increased risk is due to inherited mutations that impaired DNA mismatch repair. Two to three percentage of colon cancer is caused by Lynch syndrome. A family history of colon cancer occurs at a young age. We experienced one case of Lynch syndrome who had had stomach cancer, endometrial cancer and colon cancer recently. Hence we report this case with a brief review of literature.
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KEYWORD
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Endometrial cancer, HNPCC, Colorectal cancer, MSI (microsatellite instability), MMR (mismatch repair)
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